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How Diet and Lifestyle Influence Telomere Length

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Telomere length has a proportional and linear relationship to omega-3 fatty acids. With all the attention surrounding telomere length as a biomarker of biological aging, it’s worth pointing out that one nutrient may make a lot of difference: fish-derived omega-3 fatty acids. The higher the blood levels of fish-derived omega-3 acids in patients with coronary heart disease, the longer the telomeres. This was what was found by researchers recently from University of California, San Francisco. Omega-3 The study (Farzaneh et al. 2010), published in the January issue of JAMA last year, showed that leukocyte telomere length (LTL) was positively associated with higher blood levels of omega-3 fatty acids (see Figure). “Omega-3 fatty acids may protect against cellular aging in patients with coronary heart disease,” the authors wrote. This longitudinal study followed 608 patients with stable coronary artery disease for five years. LTL was measured at baseline and again five years later. The basel...

Depression and telomeres

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Reference: Wolkowitz et al. 2011 March. People who suffer from major depression have a higher risk of age-related illness and earlier mortality (1 &2). Researchers from University of California, San Francisco (UCSF), investigated (1) telomere length in depressed individuals versus matched controls and assessed other biological factors associated with telomere shortening. Led by Nobel laureate Elizabeth Blackburn, Ph.D., the team of researchers published their findings in the March issue of PLos One . Their hypothesis was that not all depressed subjects would show shortened telomeres equally because of a large variance in depressive episodes over a lifetime. However, they predicted that those who suffered from depression for long durations would have shorter telomeres due to longer exposure to oxidative stress and inflammation induced by psychological stress. The scientists recruited 18 subjects diagnosed with Major Depressive Disorder (MDD), excluding those with psychosis or bipol...

Health at Telomere's Length

A health checkup could soon incorporate a telomere measurement to estimate a person's biological age as a superior indicator of age-related degeneration and vulnerability to disease than chronological age, reports Mitch Leslie in an article entitled, " Are Telomere Tests Ready for Prime Time ," published in Science magazine today. The article reports that two companies have announced plans to start performing tests for the general public this year: Life Length of Madrid has already began offering the tests to patients and Telome Health, of Menlo Park, Calif., will begin to make them available to clinicians sometime later this year. Already, medical researchers have employed telomere measurement for predicting illness and tailoring treatments to save lives, yet the article reports that skepticism exists about how effective telomere tests will be in predicting disease or determining lifespan in a clinical setting. "By curtailing self-renewal, worn-down telomeres might...

How come evolution hasn’t made us immortal? Death, like sex, helps animal populations avoid extinction

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Genes do not evolve, nor do traits that are coded for our genes. We say that they evolve to facilitate discourse, which is alright. Populations evolve. A new genotype appears in a population and then either spreads or disappears. If it spreads, then the population is said to be evolving with respect to that genotype. A genotype may spread to an entire population; in population genetics, this is called “fixation”. (Human chromosomes capped by telomeres, the white areas at the ends. Telomere shortening is caused by oxidative stress, and seems to be associated with death of cells and organisms. Source: Wikipedia.) Asexual reproduction is very uncommon among animals. The most accepted theory to explain this is that animal populations live in environments that change very quickly, and thus need a great deal of genetic diversity within them to cope with the change. Otherwise they disappear, and so do their genes. Asexual reproduction leads to dramatically less genetic diversity in population...