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Changes in genetic expression during weight loss and weight maintenance

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by Amanda Jensen*  Losing weight is an ambition with no end. To get fit, live longer, reduce injury, look better, feel better and sleep better will pave the road toward your skinny. Yes, losing weight is known to help the heart and boost insulin sensitivity, but the question still asked is: how? There are differences between losing weight and keeping it off. From the Department of Clinical Sciences Malmo in Sweden, researchers found seven key genes expressed in adipose tissue (fat tissue) that change with weight loss and weight maintenance—a finding that brings science one step closer to understanding how the body responds to and regulates fat loss. This randomized controlled trial shows that the genes expressed by adipose tissue change when an obese person trims down, and stays down. "For most people," the authors report, "maintaining a reduced weight is a difficult but important task to fully obtain the beneficial effects of weight loss." Researchers placed 12 obe...

Walking Off The Influence of "Thrifty Genes"

"I can't help it, it's my genes" is a familiar phrase among frustrated dieters and gym goers who feel they can’t make the scale budge despite all efforts to reduce calories and exercise more. There may be something to their justification. After all, weight can depend partly on genetic makeup (among several other factors). Luckily, the genetic revolution continues to churn out exciting news giving us hope that, no, we're not completely left at the mercy of the wrong kind of genes. The latest example is a study presented March 14 at the American Heart Association meeting in San Diego. The study found that people could keep their obesity genes under wraps by doing as little as turning off the tube and taking a brisk walk. The study found that a brisk one-hour walk daily cut the influence of genes on obesity by as much as half! On the other hand, every couple of hours of watching television appeared to increase the influence of obesity genes by a quarter. That can m...