Posts

Showing posts with the label brain

Why you can all stop saying meat eating fueled evolution of larger brains right now

Image
Hadza returning from hunt in Tanzania. Credit Andy Lederer. In William Shakespeare's comedy  Twelfth Night,  Sir Andrew, who was worried that a joke may have been made at his expense, reasons out loud that maybe his diet had something to do with his lack of intelligence, saying, "But I am a great eater of beef, and I believe that does harm to my wit" (Act I, Scene III). Dialogue like that was how Shakespeare famously poked fun at what he considered "foolery" in his time; it was a common belief of the Elizabethan Age that eating too much meat made you a meat-head. Now, it appears the tables have turned. Vegetarians are getting a taste of similar medicine from comedians of our time. On November 15th's episode of The Colbert Report, Stephen Colbert interviewed one of the world's foremost paleoanthropologists, Chris Stringer of the Natural History Museum, about his newly published book . During their conversation, Stringer sums up nicely why meat eating may ...

Holding on to brain function through nutrition

By the year 2050, the number of people in the world over 80 years old will reach 370 million. About 50 percent of adults currently 85 and older have Alzheimer’s disease. The statistics are sobering and warn of a growing and serious epidemic. A high prevalence of Alzheimer’s disease, which is a debilitating and costly disease, can severely impact the population. With this perspective, the American Society for Nutrition hosted a symposium on the nutritional prevention of cognitive decline on Wednesday at Experimental Biology in San Diego. At the event, speakers presented a comprehensive overview of epidemiological, animal, and clinical trials regarding the role of B vitamins, omega-3s, vitamin D, and caffeinated beverages such as coffee and tea in the prevention and treatment of cognitive impairment. Martha Morris, Ph.D., an epidemiologist at Tufts University, discussed the relationship of folic acid, B12, and homocysteine to age-related cognitive decline, dementia, and Alzheimer’s dise...

Can carotenoids in the brain protect against Alzheimer’s?

Carotenoids are thought to protect against Alzheimer's disease because of their antioxidant properties and their accumulation in the brain. However, a new study from Tufts University is putting the theory into question. More than a century has passed since the German physician Dr. Alois Alzheimer first presented evidence on the case of Auguste Deter, who at only 51 suffered from severe memory loss and other psychological changes. At autopsy, Dr. Alzheimer found his patient had severe shrinkage and abnormal deposits of the nerve cells. "That was in 1906," said nutritionist Annie Roe, a USDA researcher at Tufts University, who presented her laboratory's findings on April 21 at Experimental Biology 2012 in San Diego. "There's still disparity among scientists as to the etiology of this rapidly growing disease as we now know as Alzheimer's disease." Currently, in the United States there are 5.3 million people with Alzheimer's disease. Unless new metho...

Can we get any smarter? (A conversation with my boy about neuroscience)

Image
A PET image showing energy consumption in the hungry brain. Credit:   Wiki "Can we get any smarter?" That is the question that piqued the interest of a 14-year-old boy yesterday when he saw it on the cover of the July issue of Scientific American.  What came next was a reading of Douglas Fox's fascinating "The Limits of Intelligence," some heavy thought in a young teenager's head, and a surprised father who rarely has a conversation with his son about neuroscience. Plus, that same father is rarely met when he comes home from working all day to a welcome like this, "Hi dad. Do you want to go see a cool movie?" The movie my boy wanted to see (with me!) was  Limitless,  a science fiction flick he'd seen before about a man who takes a drug that unlocks his ability to use the "other 80 percent of his brain." We went to see it and, as my son pointed out after the movie, all of what was portrayed was just  impossible . Why? I asked. And that...

Deep-brain stimulation for depression

On Sunday morning at New Horizons in Science at Yale -- after some coffee for brain stimulation -- we were treated to our first science talk of the day: on deep-brain stimulation as a treatment for severe depression. Emory University professor of psychiatry and neurology Helen Mayberg, MD , showed us several brain scans she uses to study moods and neural networks. She can tell from these neural images whether you're glad, mad or sad. Then, she targets areas of the brain with what she describes as an "implantation of a very, small wire... with electrodes on the end." The electrodes are guided to wherever she wants it in the brain and an IPG is implanted in the chest. Dr. Mayberg worried about the safety of acute stimulation of areas of the brain. What happens if you stimulate the hypothalamus and it causes a drop in blood pressure? But she couldn't rely on surgeons as "gatekeepers," so she performed intra-operative safety testing. During the testing, patients...

Dietary Interventions for Prevention and Reversal of Brain Aging

As part of Symposium II at American College of Nutrition conference in New York City, we are now enjoying a talk by PATH Medical director Eric Braverman, M.D., FACN. Braverman starts out talking about how "the brain is the most important organ" and you can have "too highs and too lows" such as in blood pressure, etc. He says he operates on the view that the purpose of being a doctor is to improve health in dramatic ways, which he adds should be measured. He has a slide up of several examples of aging patterns: "pause," "decline in," and "onset age." One example is "osteopause," "bone sensity" and "30", or "menopause," "estrogen, progesterone, and testosterone in women" and "40." Brain aging, from his perspective, has to be simplified to get anywhere. He "boils down" to loss of neurotransmitters and hormones in aging that leads to widespread down. "Aging is marked...

Helping the Brain Help Itself keynote by Mark Mattson

Now, for the second keynote at American College of Nutrition conference in New York City we're listening to Mark Mattson, Ph.D. He starts out talking about his work in the laboratory of neurosciences at National Institutes of Aging. He talks about what happens during aging in the brain. More and more as people get older, neurons age and die, predisposing us to Alzheimer's and other brain diseases. The mechanisms on how this happens are being shown and he discusses the different pathways. Dietary energy restriction, exercise, cognitive enrichment promote neuroprotection (hormesis?) by reducing oxidative stress and inflammation. Current trends in Alzheimer's showing it's a huge issue that's not being dealt with. We need a war on it like we have on cancer. Many people die from Alzheimer's and it's a tax on society. He discusses amyloid plaques and neurofibrillary tangles (with tau) that is involved in AD pathogenesis. There's a number of animal models for ...

High doses of B vitamins slow rate of shrinking brain

Unfortunately, getting older comes with a common consequence affecting up to 16 percent of elderly people – gradual reduction in brain size, which is associated with problems in learning and memory. However, a new study reports that daily supplementation with high doses of B vitamins may help slow the rate of brain degeneration. Oxford researchers gave 168 individuals over the age of 70 supplements containing high doses of folic acid (0.8 milligrams per day), B6 (20 milligrams per day) and B12 (0.5 milligrams per day), or a placebo as part of a randomized, double-blind controlled trial. Then, following two years of the supplementation program, the participants’ brains were assessed using serial volumetric magnetic resonance imaging scans. The researchers reported their results in the September issue of PLoS One: the rate of brain shrinkage, or atrophy, in the group taking the supplements was 53 percent lower in comparison to the group taking the placebo. Their conclusion was that the h...