Isa News Sept Oct2007

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Isa News Sept Oct2007

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Cortisol, surprise-enhanced cognition, and flashbulb memories: Scaring people with a snake screen and getting a PhD for it!

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Cortisol is a hormone that has a number of important functions. It gets us out of bed in the morning, it cranks up our metabolism in preparation for intense exercise, and it also helps us memorize things and even learn. Yes, it helps us learn . Memorization in particular, and cognition in general, would be significantly impaired without cortisol. When you are surprised, particularly with something unpleasant, cortisol levels increase and enhance cognition. This is in part what an interesting study suggests; a study in which I was involved. The study was properly “sanctified” by the academic peer-review process (Kock et al., 2009; full reference and link at the end of this post). The main hypothesis tested through this study is also known as the “ flashbulb memorization ” hypothesis. Interestingly, up until this study was conducted no one seemed to have used evolution to provide a basis on which flashbulb memorization can be explained. The basic idea here is that enhanced cognition with...
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Mutagenic Metals

The biochemical mechanism by which metals are mutagenic is by their effects on DNA. The main pathway shared by iron, copper, chromium, vanadium and cobalt is by redox-cycling reactions and mercury, cadmium and nickel by depleting glutathione and bonding to sulfihydryl groups (1). Free iron, in particular, can cause oxidative damage on DNA that can cause cancer in the spleen (2). Arsenic, in particular binds directly to critical thiols producing DNA damage (1). Cadmium interferes with and inhibits DNA repair (3;4). Reference List 1. Valko M, Morris H, Cronin MT. Metals, toxicity and oxidative stress. Curr Med Chem 2005;12:1161-208. 2. Wu X, Kannan S, Ramanujam VM, Khan MF. Iron release and oxidative DNA damage in splenic toxicity of aniline. J Toxicol Environ Health A 2005;68:657-66. 3. Slebos RJ, Li M, Evjen AN, Coffa J, Shyr Y, Yarbrough WG. Mutagenic effect of cadmium on tetranucleotide repeats in human cells. Mutat Res 2006;602:92-9. 4. Giaginis C, Gatzidou E, Theocharis S. DNA...
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Food is "star stuff"

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Champagne supernova. Credit: Space Daily "If you want to make an apple pie from scratch, you must first invent the universe." When you eat a slice of apple pie, or any pie, or any food at all today, on Carl Sagan Day, it may be worthwhile to reflect on this quote, one of the beloved television series host's most famous from Cosmos: A Personal Voyage. A look back at our origins is a good way to gain some perspective, amidst the accumulating scientific evidence, on how to understand our own biology and predicting ways in which we can keep our own healthy. Or, at least, that has been my conclusion. Starting at the beginning with the chemistry of life , our own evolution , and to that of our close cousins , then on to our current situation , and the future , this blog has explored all sorts of topics relating to diet and health in the past and forthcoming. Over the years, what's evident is that there exist numerous ongoing debates in the world of food, nutrition, and me...
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