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Showing posts from March, 2011

Chew your calories and drink water: Industrial beverages and tooth erosion

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Dental erosion is a different problem from dental caries. Dental erosion is defined as the removal of minerals from the tooth structure via chemicals. Dental caries are the result of increased site-specific acidity due to bacterial fermentation of sugars. Still, both have the same general result, destruction of teeth structure. Losing teeth probably significantly accelerated death among our Paleolithic ancestors, as it does with modern hunter-gatherers. It is painful and difficult to eat nutritious foods when one has teeth problems, and chronic lack of proper nutrition is the beginning of the end. The table below, from Ehlen et al. (2008), shows the amount of erosion that occurred when teeth were exposed to beverages for 25 h in vitro. Erosion depth is measured in microns. The third row shows the chance probabilities (i.e., P values) associated with the differences in erosion of enamel and root. These are not particularly enlightening; enamel and root are both significantly eroded. The

Fusing aging theories: Telomere shortening causes mitochondrial dysfunction

New research is adding insight and linking three theories of aging—one that suggests telomere shortening governs lifespan, and two others that suggest dysfunctional mitochondria or oxidative stress leads to aging. At Harvard-affiliated Dana-Farber Cancer Institute, scientists have gathered data suggesting telomere shortening is the cause of mitochondrial dysfunction and diminished antioxidant defenses. Together, they decrease the body’s energy and diminish organ function, both characteristic of old age. As telomeres—protective caps at the end of cell chromosomes—shorten with age and begin to fray, cells activate the p53 gene, which signals an “emergency shutdown” chain of events that turns off normal cell growth and division and compromise antioxidant defenses. Going one step further, data from the carefully orchestrated mouse study, published in Nature, show that the p53 gene also represses PGC1-alpha and PGC1-beta. These PCGs are considered the master regulators of metabolism and mit

Health markers varying inexplicably? Do some detective work with HCE

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John was overweight, out of shape, and experiencing fatigue. What did he do? He removed foods rich in refined carbohydrates and sugars from his diet. He also ditched industrial seed oils and started exercising. He used HealthCorrelator for Excel (HCE)  to keep track of several health-related numbers over time (see figure below). Over the period of time covered in the dataset, health markers steadily improved. For example, John’s HDL cholesterol went from a little under 40 mg/dl to just under 70; see chart below, one of many generated by HCE. However, John’s blood pressure varied strangely during that time, as you can see on the chart below showing the variation of systolic blood pressure (SBP) against time. What could have been the reason for that? Salt intake is an unlikely culprit, as we’ve seen before . As it turns out, John knew that heart rate could influence blood pressure somewhat, and he also knew that his doctor’s office measured his heart rate regularly. So he got the data fr

Potassium iodide: Why you should avoid it

Ever since the news of Japan's nuclear crisis, there have been several claims made over the Internet that have panicked people in the U.S. about potential exposure to radiation (one culprit is this viral e-mail ), which has led to me being the recipient of questions about whether or not people should be taking potassium iodide supplements to avoid absorption to radioactive iodine. Should you take potassium iodide pills? My answer has been an unequivocal, "No, it's not necessary. There is little risk of any level of radiation exposure to worry about anywhere else other than in Japan near the reactors. If you're worried about getting cancer, try thinking more about losing weight, eating more dietary fiber, and eating more fruits and vegetables." In the process of answering questions, I did find myself interested in learning more about radiation and health. By far the best, most in-depth article I've read on "How Radiation Threatens Health" is this one

We share an ancestor who probably lived no more than 640 years ago

This post has been revised and re-published . The original comments are preserved below. Typically this is done with posts that attract many visits at the time they are published, and whose topics become particularly relevant or need to be re-addressed at a later date.

The China Study II: Fruit consumption and mortality

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I ran several analyses on the effects of fruit consumption on mortality on the China Study II dataset using WarpPLS . For other China Study analyses, many using WarpPLS as well as HCE , click here . The results are pretty clear – fruit consumption has no significant effect on mortality. The bar charts figure below shows what seems to be a slight downward trend in mortality, in the 35-69 and 70-79 age ranges, apparently due to fruit consumption. As it turns out, that slight trend may be due to something else: in the China Study II dataset, fruit consumption is positively associated with both animal protein and fat consumption. And, as we have seen from previous analyses (e.g., this one ), the latter two seem to be protective. So, if you like to eat fruit, maybe you should also make sure that you eat animal protein and fat as well.

Vitamin K2: Building bones while beating back arterial calcification

Vitamin K2's time to shine has come—move over vitamin D! Once only known for its role as a "koagulation" factor in blood clotting, vitamin K2 is emerging as another fundamental anti-aging nutrient. While vitamins D and E have garnered the majority of interest in the last decade, the impact of vitamin K2 on aging bones and hearts demands that we give it equal attention. Whereas most vitamin and mineral supplements use vitamin K in its form of K1 (phylloquinone sourced from plants) because it is easily available and cheap, it is the natural form of K2 (menaquinone sourced from friendly bacteria) that is the most biologically active and shown to enhance both bone formation and vascular health. The full compilation of recent research underscores the idea that K1 and K2 should be appreciated as separate nutrients with distinct physiological actions and benefits. K1 is the more familiar vitamin known for its key role in directing blood-clotting in the body and the one given as